However, there were certain pathways such as hedgehog signaling (R = 0.371, P-value = 0.03 for LGG and R = 0.588, P-value = 0.02 for KIRC), oxidative phosphorylation (R = 0.353, P-value = 0.04 for LGG), Wnt beta catenin (R = 0.434, P-value = 0.01) and KRAS signaling up (R = -0.503, P-value = 0.05) which were specifically significantly correlated with the PANoptosis score across cancer cell lines (Fig. 5A) with contrasting correlation patterns to PANoptosis phenotype when compared to corresponding patient-derived tumors from TCGA (Fig. 4A). This evidence concerns the gene CTNNB1 and cancer.