SHC1 and cancer: Pathways such as apoptosis, Myc-mediated apoptosis signaling, SHC1/pSTAT3 signature and TNFR1 signaling were significantly positively correlated with the PANoptosis score across multiple cell types (Fig. 6B) and aligned well with the PA observed in primary tumor clusters via bulk RNA-Seq in SKCM cancer (Fig. 4B).