Regarding tumor stages, OX+ subtypes often have more advanced stages, such as T2/T3 (p-value < 0.01, Supplementary Fig. 2C) and N1/N2 (p-value = 0.02, Supplementary Fig. 2D), whereas IM+ subtypes predominantly have more localized stage tumors, like T1 and N0. This evidence concerns the gene HCRT and neoplasm.