Further, we have shown that silencing of METTL9 significantly increased Erastin-induced growth inhibition (Fig. 4G, Fig S2D) and cell death(Fig. 4I) in HCC cells, while overexpression of METTL9 decreased Erastin-induced growth inhibition and cell death in Huh7 cells (Figs. 4H, J). This evidence concerns the gene METTL9 and hepatocellular carcinoma.