The significant KEGG pathways (adjusted p < 0.05) of 309 significantly expressed genes in responders included calcium signaling pathway, motor proteins, cGMP − PKG signaling pathway, circadian entrainment, arrhythmogenic right ventricular cardiomyopathy, as well as 4 pathways identified by GSEA enrichment analysis (Fig. 5A). This evidence concerns the gene IMMT and Right ventricular cardiomyopathy.