MYC (8q24.21), NCOR1 (7p12-11.2), PHOX2B (4p13) and TP53 (17p13.1) were the top 4 commonly mutated genes, and mutated in 32%, 28%, 28% and 24% of osteosarcomas, respectively (Fig. 1A). The gene discussed is TP53; the disease is osteosarcoma.