In addition, ECM-receptor members including COL1A1, COL1A2 and COL6A3 were associated with RFS and showed significantly lower expression in tumor samples than in controls, with lower expression associated with longer survival rate (Cox adj.P values < 0.05, Fig. 3b and Supplementary Data 6), which suggested that the receptors mediating the association between cellular and matrix components are altered in the EOC. Here, COL6A3 is linked to neoplasm.