AKT1 and neoplasm: As for KEGG pathways, DNA replication, cell cycle, HIF-1 signaling pathway and several metabolism-related pathways were overrepresented in proteins upregulated in tumor samples, whereas PI3K-Akt signaling pathway and focal adhesion and extracellular matrix (ECM)-receptor interaction were overrepresented in downregulated proteins (Fig. 2c and Supplementary Data 4).