Tumor selectivity was conferred to replication-competent OAds by inserting a modified hTERT (mhTERT) promoter to drive the expression of the E1 gene in which a 24-bp sequence in the E1A region and an E1B55-kD viral protein in the E1B region were deleted (Fig. 2a).25,26 The mhTERT promoter produced significantly higher luciferase gene activity than the wild-type hTERT promoter (wt-hTERT) in mouse tumor cells (GL261, MC38, LL/2, 4T1, and CT26) but a low level of luciferase gene activity in normal mouse 3T3-L1 cells (Supplementary Fig. 3). The gene discussed is DHTKD1; the disease is neoplasm.