Based on the composition and phenotypic states of intratumoral immune cells in the different tumor types and even the expression of ligands, CD47 and CD24 were rationally selected as targets to restore macrophage-mediated phagocytosis in macrophage-dominated tumors, while CD155 was used as a target to prevent T-cell exhaustion in CD8+ T-cell-dominated tumors. Here, CD47 is linked to neoplasm.