MAPK3 and neurodevelopmental disorder: Additionally, MAPK3 is located in a 593 kb recurrent deletion region on 16p11.2, which is associated with neurodevelopmental disorders, and MAPK3 has a Simons Foundation Autism Research Initiative (SFARI)57 gene score of 2 (“Strong Candidate”), with 11 rare variants (10 missense variants, one stop loss variant) reported in genetic studies on ASD.