A distal human cis-regulatory element (CRE) (h-FLT3) approximately 170 kb upstream of FLT3 showed significantly higher chromatin accessibility in MLL-r ALL cells (SEM and RS4;11 cells), as compared with non-MLL-r ALL cells (697, Nalm6, REH, SUPB15, and UOCB-1 cells) (Fig. 2A). Here, KMT2A is linked to acute lymphoblastic leukemia.