These data may appear confusing at first glance: (1) bulk RNA levels of INPP5D are elevated in the AD brain (Supplementary Fig. 2a); (2) intensity of immunostaining signal for INPP5D in microglia is elevated in plaque-associated microglia in the brain (Fig. 2d, e); and (3) full-length aqueous-soluble INPP5D protein levels are reduced in the AD brain (Fig. 2j, k). Here, INPP5D is linked to Alzheimer disease.