Only one pathway was significantly associated in all three comparisons: genes in the TNFR2 non-canonical NFκB pathway are downregulated at the RNA level in microglia in the postmortem AD brain and are also downregulated in iMGs with INPP5D loss-of-function (Fig. 7k); genes associated with this pathway were upregulated with INPP5D overexpression (Fig. 7k). This evidence concerns the gene INPP5D and Alzheimer disease.