Multiple pathways relevant to inflammasome signaling were altered with INPP5D loss-of-function and are aligned with patterns observed in AD brain microglia (compared to LP-NCI brain microglia) while pathways altered with INPP5D overexpression are more similar to those in LP-NCI brain microglia (compared to AD) (Fig. 7k). Here, INPP5D is linked to Alzheimer disease.