Quantification of INPP5D in urea-solubilized human brain tissue by western blot revealed slightly reduced levels of INPP5D in the population of AD brain tissues relative to NCI individuals, with lower levels in AD relative to HP-NCI (Supplementary Figs. 3 and 4, Supplementary Data 11, Supplementary Data 2). Here, INPP5D is linked to Alzheimer disease.