Another study has shown that hesperidin, which is a flavonoid found in lemons and other citrus fruits, can restore neurogenesis in the hippocampus of mice with Alzheimer’s disease and improve memory function through the activation of AMP-activated protein kinase/BDNF/TrkB/CREB signalling(36). This evidence concerns the gene CREB1 and early-onset autosomal dominant Alzheimer disease.