Furthermore, a microarray analysis identified a panel of hypoxia-responsive genes and among genes highly upregulated by hypoxia were CA9, CASP14, LOX, GLUT3, SERPINE1 and highly downregulated AREG, EREG, CCNB1 and KIF14. Moreover, further network analysis has revealed the involvement of the microarray-identified genes in cancer, cell death and survival as well as cellular assembly and organization. This evidence concerns the gene SERPINE1 and cancer.