An in-depth mechanistic study showed that the content of cyclin A2 and cyclin-dependent kinase were decreased by high expression of GSDMD via ERK1/2, STAT3, and PI3K/AKT inhibition, suppressing S/G conversion in GC cells and exerting the anti-GC capacity of GSDMD (70–72). The gene discussed is MAPK3; the disease is gastric cancer.