GSDMD and glioblastoma: (86) demonstrated that benzimidazoles had potent activity of averting GBM by inducing GBM cell cycle arrest at the G2/M stage through the P53/P21/cyclin B1 signaling pathway, and simultaneously inducing chondriosome-dependent apoptosis and triggering GBM cell pyroptosis via the NF-κB/NLRP3/GSDMD signaling pathway in vivo and in vitro.