Virtually all chemotherapy medicines can induce PD-L1 translocation and upregulation of GSDMC, whereas only the antibiotics such as doxorubicin, epirubicin, daunorubicin, and actinomycin D can activate caspase-8, induce GSDMC cleavage, and induce pyroptosis in MDA-MB-231 breast cancer cells. Here, CD274 is linked to breast carcinoma.