GSDMD and ovarian cancer: In addition, the content of NLRP3, caspase-1, GSDMD, IL-18, and IL-1β was markedly up-regulated in cells treated with CA, implying that CA accelerates pyroptosis of ovarian cancer cells via the TXNIP/NLRP3/caspase-1/GSDMD axis-mediated canonical and caspase-4/GSDMD-mediated non-canonical pyroptosis pathways (123).