BDNF and type 1 diabetes mellitus: In non-obese diabetic (NOD) mice that naturally develop type 1 diabetes, high glucose (>200 mg/dL) leads to an increase of vascular endothelial growth factor (VEGF) and a decrease of neuroprotective brain-derived neurotrophic factor (BDNF), along with reduced levels of SIRT6 protein and increased levels of H3K9Ac and H3K56Ac in the retina (Zorrilla-Zubilete et al., 2018).