Consistent with these results, metabolomic comparisons of wild-type and Sirt6 ko mouse ESCs and SH-SY5Y neuroblastoma cells showed substantial differences in mitochondrial metabolite abundance in SIRT6-deficient cells, which was accompanied with elevated ROS production, decreased mitochondrial number, and reduced membrane potential (Smirnov et al., 2023). Here, SIRT6 is linked to neuroblastoma.