Considering the defects of autophagy as one of the possible mechanisms for developing AMD, particularly the appearance of drusen deposits in dry AMD (Mitter et al., 2014; Golestaneh et al., 2017; Lakkaraju et al., 2020; Kaarniranta et al., 2023), SIRT6 could be a potential preventive and/or therapeutic target for AMD through activation of autophagy. The gene discussed is SIRT6; the disease is dry age related macular degeneration.