SIRT6 and diabetes mellitus: Furthermore, gene expression profiling and Gene Ontology enrichment analysis of Müller cells from a streptozotocin-induced rat model of diabetes showed enrichment of genes associated with glucose metabolism, cell migration, development, and pluripotency, many of which were related to SIRT6 functions (Gerhardinger et al., 2005; Sanhueza Salas et al., 2021).