From the viewpoint of physiological roles of SIRT6, it should be noted that SIRT6 inhibition is beneficial in the case of metabolic reprogramming to attenuate retinal degeneration, while many favorable effects of SIRT6 result from its activation or overexpression in other contexts such as inflammation, oxidative stress, and DNA repair, as described earlier. The gene discussed is SIRT6; the disease is retinal degeneration.