Quantification of plasma cardiac troponin I and T (cTnI and cTnT) and of the N-terminal fragment of the probrain natriuretic peptide (NT-pro-BNP) levels, clinically relevant markers of cardiac damage and heart failure, respectively, did not reveal any difference between PBS-injected and rAAV-ΔNter2-GDe–injected animals 1 month and 3 months after injection (Supplemental Figure 16E). Here, TNNI3 is linked to heart failure.