Although no known pathogenic variants were detected in other PID/IEI-associated genes, heterozygous variants of uncertain significance (VUS) were detected in other PID/IEI–associated genes (B.I.1: CLPB, MTOR; C.II.1: AK2, ARHGEF1, TAP2, SKIV2L) (Supplemental Table 2). This evidence concerns the gene AK2 and pelvic inflammatory disease.