As reported,15 the PNPLA3 risk allele c.444C>G, rs738409 encoding the PNPLA3-I148M variant is overrepresented in patients with HCC, where the [CG] and [GG] allele combinations are present in more than 80% of the patients (Figure 5A). This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.