Whereas the combination of MIF with IL-4, IL-17A, or PDGF-BB led to AUC values of 0.94 (Figure 4C, Table 3), the association of MIF with MIG as second parameter increased the AUC from 0.91 to 0.95, leading to the best predictive model for discrimination of HCC within this cohort of individuals with chronic liver diseases. This evidence concerns the gene MIF and hepatocellular carcinoma.