Interestingly, while IL-1Ra has a negative correlation with MCP-1 in healthy samples (R=− 0.76), it shows a positive correlation (R = 0.8) in NAFLD-Cirr samples (Supplemental Figure S1C, http://links.lww.com/HC9/A629). The gene discussed is CCL2; the disease is metabolic dysfunction-associated steatotic liver disease.