Among patients with children, the risk of depression was associated with children’s physical illness (OR, 3.30; 95% CI, 1.29-8.42), mother and other family members being primary caregivers (OR, 1.97; 95% CI, 1.16-3.32), GnRH treatment (OR, 1.93; 95% CI, 1.18-3.14), CSHQ–Sleep-Disordered Breathing score (OR, 1.78; 95% CI, 1.17-2.72), and total K-PSI-SF score (OR, 1.06; 95% CI, 1.04-1.07) (Table 3). This evidence concerns the gene GNRH1 and major depressive disorder.