Overall, this work deepens our understanding of the circuitry through which Yak1 regulates C. albicans morphogenesis under host-relevant conditions, implicates Pom1 as a regulator of filamentation, and unveils Yak1 as a key regulator of virulence in a mouse model of C. albicans dermatitis. The gene discussed is HIPK3; the disease is dermatitis.