Interestingly, there are some data suggesting that some of the common genetic alterations may be associated with particular immune environments, for example, in a small study, loss of BAP1 in peritoneal mesothelioma correlated with an inflammatory tumour environment [47], and CDKN2A deletion was associated with a PD-1-resistant phenotype [48]. The gene discussed is CDKN2A; the disease is neoplasm.