CXCR2 and periodontitis: In contrast, the proportion of neutrophils expressing CXC motif chemokine receptor (Cxcr2) (Hashim et al., 2021) and G0/G1 switch gene 2 (G0s2) (Zhang et al., 2017) increased after ligature placement and during periodontitis development from days 1–7 (Figure 5A and B, Figure 5—figure supplement 1), suggesting continuous neutrophil infiltration into the early and established gingival lesion.