Seven genes were identified in mass spectrometry and bioinformatic analysis, all significantly downregulated in pancreatic cancer (GEO data, GSE32676),[33] including TSPYL2, TSR1, METAP2, CYR61, EBF2, CIRBP, and TGFBR3. The gene discussed is TSPYL2; the disease is familial pancreatic carcinoma.