Some reasons why this study focused on two protein markers RhoB10, 62 and DNp7363, 64 are because of their relevance to this cancer type (different cancers can have distinct molecular profiles, and specific protein markers may be more relevant to one type of cancer than another), biological significance (RhoB and DNp73 have known roles in colorectal cancer progression, making them of interest for prognosis studies), and hypothesis testing (RhoB and DNp73 are hypothesized to have valuable prognostic information for colorectal cancer). Here, RHOB is linked to colorectal cancer.