Here, we show that tumours induced by the overexpression of RasV12 and an RNAi against the polarity protein Scribble (scribRNAi) using the QF/QUAS system, caused a downregulation of insulin signalling (pAkt, Fig 1B–D), and an upregulation of TGF‐β signalling (pMad, Fig 1E–G) in the fat body. This evidence concerns the gene INS and neoplasm.