Interestingly, while muscle pMad levels are elevated in tumour‐bearing animals and that tumour‐specific ImpL2 inhibition was able to reduce muscle TGF‐β signalling in tumour‐bearing animals (Fig EV3Q–S); muscle‐specific expression of madRNAi in tumour bearing animals (QRasV12, scribRNAi) using MHC‐GAL4 (Fig EV3T) was not able to improve muscle integrity. The gene discussed is HLA-C; the disease is neoplasm.