SYNE4 and hearing loss disorder: Several studies have been conducted on the use of AAV for gene therapy of hereditary deafness, and some specific forms of hereditary hearing loss can be restored by gene delivery or gene editing in hair cells, e.g., deafness caused by Tmc1 deletion, Ush1c c.216G>A, Kcnq1 deletion, Strc deletion, Syne4 deletion, Tmc1 c.1253T>A, etc.,[6, 7, 8, 9, 10, 11, 12, 13] thus indicating the promising application of AAV‐based gene therapy in the treatment of hereditary hearing loss.