The GWAS signal for PNPLA3 is strongly associated with NAFLD and also with a NASH cohort (48) and variants in PLIN2, KLF6, UCP3, and MARC1 (49) are associated with liver steatosis, fibrosis, cirrhosis, or NAFLD. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.