Nevertheless, in this study, the GLP-1RA liraglutide reduced mRNA levels of fibrosis markers (Col1a1, Col1a2, Col3a1, Lamb1, and Timp1) and the synthesis rate of collagen I but showed mixed responses in staining of fibrosis markers: decreases in α-SMA and Col1a1 with no significant changes in Col IV and PSR were observed compared with NASH Vehicle. The gene discussed is COL1A1; the disease is metabolic dysfunction-associated steatohepatitis.