Two tumor suppressors involved in epigenetic regulation were progressively lost in LGSC and its corresponding metastasis (ZMYND10, OSCP1/NOR1), as was Anterior Gradient Protein 2/3 (AGR2/3) previously implicated in the progression of SBT to LGSC16 (Extended Data 2b). The gene discussed is OSCP1; the disease is neoplasm.