In fact, RNAseq profiling 85 minutes after the MAST revealed a subtype-specific differential response of Coiled-Coil Domain Containing 196 (CCDC196) (logFC = 2.10, pFDR = 0.00063) and Spermatogenesis Associated 33 (SPATA33) (logFC = −0.87, pFDR = 0.0495) significantly differentially expressed between Hyperphagic MDD and Hypophagic MDD (Fig. 3A–B, QQ-plot in Supplemental Fig. 3, full list of nominal significant DEGs in Supplemental Table 3). Here, SPATA33 is linked to major depressive disorder.