At baseline T0 when controlling for age, BMI, sex, calories of breakfast intake, sequencing quality, and repeated measures, the expression of transcriptional adaptor 2-beta (TADA2B) gene was significantly increased in the Hyperphagic MDD group in comparison to the Hypophagic MDD group after controlling for multiple testing (logFC = 0.22, pFDR = 0.013) (Fig. 2A, QQ-plot in Supplemental Fig. 2, full list of nominal significant DEGs in Supplemental Table 1). This evidence concerns the gene TADA2B and major depressive disorder.