Interestingly, some of these 55 HPPs are involved in RTKs Signaling, proteoglycans in cancer, cell morphogenesis, hemopoiesis, PID CXCR4 pathway, epithelial cell differentiation, Cytokine Signaling in the Immune system, adherens junction, regulation of kinase activity, cellular response to lipid, head, and neck SCC, response to wounding, Hippo signaling regulation, Interferon type I signaling, PI3K-Akt signaling, leukocyte activation, response to estradiol, lymphocyte activation, Th1, and Th2 cell differentiation, and NK cell-mediated cytotoxicity (Fig. 5C, Table S4; P-value < 0.05). Here, AKT1 is linked to cancer.