ACE2 and COVID-19: In addition to the response observed for IL-6 and IL-8, inflammatory chemokines CCL2 and CCL7 which are found in the bronchoalveolar fluid of severe COVID-19 patients [102] were also observed to downregulate after 6 h treatment of alveolar epithelial with cannabis [98] and ACE2 expression was also found to be downregulated after 4–6 h post cannabis treatment [98, 103].