ZEB2 and liver dysplastic nodule: Therefore, a sustained increase in HIF1α is a major adaptive stimulus to the hypoxic conditions.[2] By regulating its target ZEB2 gene (Zinc finger E-box-binding homeobox 2), it affects pathological and physiological processes such as glucose, energy metabolism, inflammation, and plays an essential role in the occurrence and development of DN.[3–5] There is a growing body of evidence that hypoxia can cause kidney damage, inflammatory reactions, loss of podocytes and abnormal function, and reduced glomerular filtration rates leading to proteinuria.