GH1 and Alzheimer disease: Sleep disturbance, which characterized with decreased sleep duration, low sleep efficiency, and increased awakenings, had considered to be the biggest impact on shorter stature in children with AD.[9] The more severe the disease, the worse the quality of sleep.[10] Growth hormone (GH) is closely related to height growth in children; it peaks immediately subsequent to sleep onset.[11] Therefore, sleep disturbance can affect the secretion of GH, resulting in stunted growth and development.