By releasing IL-6 and IL-8, and amphiregulin, senescent fibroblasts have been shown to affect the tumor microenvironment by promoting monocyte differentiation into pro-inflammatory M2 macrophages and driving PD-L1 expression in tumor cells.[55,56] The impact of senescent fibroblasts of human aging on the tumor immune response through their SASP remains unclear and requires further investigation. This evidence concerns the gene AREG and neoplasm.