CD8A and neoplasm: Studies have demonstrated the critical role of CD8 T-cell immunosenescence in both tumor development and treatment.[39] Age-related alterations in immune response have been observed in aged mice, including reduced expression of interferon (IFN) signaling in CD8 T-cells.[40] The TME is significantly influenced by the aging process, with a demonstrated impact on the metabolism of T-cells within it, closely linked to tumor metastasis and infiltration.