The core lactylation-associated gene CALML5 and hub CALML5-associated lncRNAs MIRLET7BHG, AL162457.2, AL122010.1, MIR193BHG, AC244153.1, AL390760.1, AL133371.2, and CCDC18-AS1 have the potential to serve as biomarkers for the prognosis of CM patients and reflect their immune conditions. Here, CCDC18 is linked to cutaneous mastocytosis.