CALML5 and cutaneous mastocytosis: To further confirm the predictive accuracy of lactylation-associated genes in predicting the occurrence of CM, it was discovered that genes CALML5 and WAS had high predictive value with AUC > 0.9, and genes CRABP2, GATABP2, LAP3, MDC1, SATB1, and TMSB4X had moderate predictive value in CM with AUC > 0.7 (Fig. 4F).