CALML5 and melanoma: WAS is a member of WASP family which has been proved to play a virtual role in melanoma cells migration and invasion through reorganizing actin cytoskeleton.[16,17] However, concerning the role of CALML5 in CM, there is currently only 1 reference indicating the differential expression of CALML5 in the CM clusters,[18] its specific prognostic value and modulation mechanism in CM remains unclear.