CYGB and osteosarcoma: When evaluating localized osteosarcoma, the union model (clinical + radiomics) could increase the value of the evaluation over clinical factors alone.[63] In terms of predicting early recurrence of osteosarcoma, Liu et al[64] discovered that hemoglobin (HGB) level and joint invasion are effective for predicting relapse risk in osteosarcoma patients; hence, HGB level and joint invasion were used to develop the clinical nomogram, and the radiomics nomogram was developed by fusing the radiomics signature and clinical-based risk factors.