TP53 and psoriasis: Furthermore, SPRPs play a vital role in free radical cleansing, directly protecting chromosome damage and the p53 signaling pathway.[50]SLURP2, a psoriasis-related gene was found to be upregulated in the hyperproliferative skin cells.[51] Researchers have found that treating keratinocytes with IL-22 increased SLURP2 expression, which may be related to skin homeostasis or pathological formation of skin diseases.[47]KRT16 is a member of the keratins which are the major structural intermediate filament proteins in keratinocytes and are expressed in a specific pattern in different subtypes.