The key protein results of MCODE algorithm indicated that the pro-inflammatory factors IL-1α, IL-1β, IL-2, and IL-6 and the anti-inflammatory factors IL-4 and IL-10 may be the key immune network targets of RA, and the active compounds in STZY may play a role in treating RA by regulating the balance of immune network targets. Here, IL1B is linked to rheumatoid arthritis.