The ARID2 high-subgroup was significantly enriched in bladder cancer, epithelial cell signaling in Helicobacter pylori infection, Legionellosis, renin–angiotensin system, and Type II diabetes mellitus, yet complement and coagulation cascades, glycosaminoglycan biosynthesis − heparan sulfate/heparin, hepatitis C, Staphylococcus aureus infection, and SLE had significant enrichment in the low ARID2 subgroup (Fig. 7A). The gene discussed is REN; the disease is urinary bladder cancer.