The red cluster mainly contains oxidative stress, heart failure, cardiac hypertrophy, induced apoptosis, necrosis, cardiac fibrosis, endoplasmic reticulum, cardiomyopathy, diabetic cardiomyopathy, activated protein-kinase, nuclear factor-κB, tumor necrosis factor-α, Ca2+, nitric oxide synthase and so on. This evidence concerns the gene TNF and heart failure.