The literature with the highest betweenness centrality was published in Circulation Research “MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD” (0.21).[22] This was followed by a publication in Nature Medicine entitled “CaMKII is a RIP3 substrate mediating ischemia-and oxidative stress-induced myocardial necroptosis” (0.17).[23] Figure 5B shows the top 20 publications with the strongest citation bursts, with the Lancet’s “Acute myocardial infarction article” having the highest citation strength of 20.25.[21]. The gene discussed is RIPK3; the disease is ischemia.