As a result, the early detection and intervention of prediabetes can reduce the incidence of diabetes and its complications.[9,10] On the other hand, IR, a strong predictor of prediabetes, has been linked to glucose intolerance, obesity, dyslipidemia, cardiovascular disease, and cancer.[8] A growing body of evidence suggests that IR is a complex metabolic disorder with multiple pathophysiological mechanisms.[11] Defective insulin receptors or post-receptors compromise hormonal signal transduction mechanisms, resulting in IR. The gene discussed is INSR; the disease is prediabetes syndrome.