The prevalence of hyperthyroidism and Graves’ disease (GD) in women is mostly in the age of 30 to 60 years old, and the prevalence of hyperthyroidism and GD in women is significantly decreased after 60 years old.[4] The Thyroid hormone affects almost every cell in the body, untreated or even subclinical hyperthyroidism can lead to an increased risk of atrial fibrillation, stroke, and other cardiovascular events, as well as osteoporosis and fractures.[5–7]. This evidence concerns the gene TG and hyperthyroidism.