IGF2BP3 and colorectal carcinoma: Jin et al found that circHIPK3 interacts with miR-654 to increase IGF2BP3 expression, which enhances the proliferation and metastasis of glioma cells.[84] Additionally, Zeng et al elucidated that circHIPK3 is also highly expressed in CRC tissues and acts as an oncogene role in CRC by targeting miR-7.[85] Although the role of circRNAs on m6A regulators has not been reported in CRC, based on the above-mentioned research, we speculate that circRNAs may participate in the regulation of m6A modification via miRNAs in CRC, and this needs further experiments to validate.