YTHDF1 and colorectal carcinoma: Interestingly, they found that c-myc, an oncogenic transcription factor, can bind in the 5′UTR of YTHDF1 but not others in the YTH family to promote its transcription in CRC, implying the critical role of c-myc in YTHDF1 expression.[92] However, this study did not explore whether the regulation of c-Myc in YTHDF1 influences the m6A modification.