In particular, ZC3H13 suppresses CRC proliferation and invasion by decreasing the expression of Snail, Cyclin D1, and Cyclin E1 and increasing the expression of Occludin and Zo-1 to inactivate Ras–ERK signaling pathway.[54] In summary, the regulation of m6A modification on mRNA stability might depend on the interaction between m6A “writers” and corresponding m6A “readers,” which are responsible for mRNA stability and degradation. The gene discussed is ZC3H13; the disease is colorectal carcinoma.