Mechanically, m6A-modified XIST can be recognized and bonded by YTHDF2, which promotes XIST degradation.[70] This study emphasizes the inhibitory effect of METTL14 in CRC and reveals a novel mechanism of m6A in CRC, which may provide a new sight for CRC therapeutic strategies in the future. This evidence concerns the gene YTHDF2 and colorectal carcinoma.