METTL3 and colorectal carcinoma: This result suggested that YTHDF1 may play an important role in immunity regulation.[115] Wang et al reported that inhibition of m6A levels, caused by the depletion of METTL3 and METTL14, promotes the sensitivity of CRC to PD-1 treatment by increasing cytotoxic tumor infiltrating CD8+ T cells and the production of cytokine including IFN-γ, Cxcl9, and Cxcl10.