SPRED2 and colorectal carcinoma: The mature miR-1246 reduces the expression of an anti-oncogene sprouty related EVH1 domain containing 2, therefore interacting with the Raf/MEK/ERK pathway to promote CRC metastasis.[62] METTL14 has also been demonstrated to regulate the maturation of miRNAs and identified as a tumor suppressor in CRC.