Previous studies suggested that METTL3 can not only regulate the mRNA stability but also promote the mRNA translation in an m6A-dependent or independent manner.[29] As reported by Vu et al[55] in human acute myeloid leukemia cells, METTL3 promotes the translation of c-MYC, B-cell lymphoma 2 and phosphatase and tensin homolog mRNAs dependent on its methylation activity. Here, METTL3 is linked to acute myeloid leukemia.