METTL3 and colorectal carcinoma: Further study showed that m6A-modified CBX8, caused by METTL3, maintains the stemness properties of colon cells and inhibits the chemosensitivity of colon cancer cells to oxaliplatin and irinotecan by upregulating leucine rich repeat containing G protein-coupled receptor 5.[112] Additionally, the knockdown of YTHDF1 enhances the sensitization of CRC cells to 5-FU and L-OHP.