AKT1 and colorectal carcinoma: Berberine, an isoquinoline alkaloid, is the basic component of Coptidis Rhizoma with multiple pharmacological activities.[103] Zhang et al found that berberine decreases the IGF2BP3 expression and inhibits the activity of the PI3K/AKT pathway in CRC, leading to the block of cycle transition and inhibitor of proliferation.[104]