METTL3 and familial pancreatic carcinoma: Kupsco et al found that the total RNA m6A levels were lower in men with long-term smoking by detecting the levels from the peripheral blood samples.[105] Zhang et al found that cigarette induces METTL3 hypomethylation, resulting in the upregulated expression of METTL3, which promotes oncogenic miR-25-3p maturation and contributes to the progression of pancreatic cancer.[106] However, the association between cigarettes and m6A modification in CRC is needed to explore.