It is well known that the development of CRC is a complex process, including the interaction between environmental factors and genetic factors.[3,4] For example, β-catenin and cyclooxygenase 2 have been demonstrated to closely participate in the occurrence and development of CRC.[5] Recently, RNA methylation modification, as an important part of post-transcriptional regulation, has become an emerging research focus in the field of epigenetic inheritance in tumors. The gene discussed is PTGS2; the disease is colorectal carcinoma.