METTL3 was highly expressed in CRC tissues and associated with poor survival.[40,42,62] The higher expression of METTL14 shows a negative association with poor overall survival in CRC patients.[63,70] The upregulation of YTHDF3, YTHDF1, IGF2BP2 or the downregulation of ALKBH5 is significantly related to poor overall survival in CRC patients.[71,75,83,92,110] Collectively, m6A might be a potential biomarker for the diagnosis and prognosis of CRC. The gene discussed is ALKBH5; the disease is colorectal carcinoma.