Neurofibromas are the most common neoplasms associated with NF-1, but malignancies such as MPNST, non-lymphocytic leukemias, gliomas, pheochromocytomas, and gastrointestinal stromal tumors may also develop.[3,4,6]. This evidence concerns the gene NF1 and hereditary pheochromocytoma-paraganglioma.