EPHX2 and chronic obstructive pulmonary disease: The levels of inflammation in lung tissue correlate with autophagy levels; CS can cause autophagy and thus COPD, Yunxiao Li’s study[72] with adult male wild-type (WT) C57BL/6J and Ephx2-/- mice suggested that Ephx2 may hold promise as a therapeutic target for CS-induced COPD, and may play a protective role in lung tissue by inhibiting autophagy and resisting inflammation, supporting the idea that autophagy is enhanced and Ephx2 lacks inhibition of autophagy in a mouse model of COPD.