Injection of lentivirus containing miR-3968 or shUBE2K into the hippocampus of APP/PS1 mice partially rescued memory impairments in both MWM and NOR tests (Fig. 6a–c, Additional file 1: Fig. S6), restored the density, maturation, and complexity of neuronal dendrites (Fig. 6d–i), and reversed the protein levels of synaptic proteins in APP/PS1 mice (Fig. 6j, k), suggesting that downregulation of the circRIMS2/miR-3968/UBE2K pathway remarkably rescued synaptic and memory impairments in AD. Here, APP is linked to memory impairment.