APP and memory impairment: For instance, Song et al. [14] reported that circCwc27 interacts with purine-rich element-binding protein A (Pur-α), halts nuclear transport of Pur-α, reduces Pur-α binding to the promoter of amyloid precursor protein (APP), and leads to Aβ deposition and memory impairment in 6-month-old APP/PS1 mice.