For example, perturbations of the angiopoietin-2 -Tie 2 axis, a regulator of capillary permeability, have been observed in both sepsis [112, 113] and AMI-CS [114] with elevations of angiopoietin-2 associated with both poor outcome and coronary reperfusion success. The gene discussed is ANGPT2; the disease is Cowden syndrome 1.