In an experimental model, PDGFA enhanced the growth of IDH1R132H mutant immortal Cdkn2a, Atrx, and Pten deficient astrocytes and PDGFA cooperated with IDH1R132H and loss of Cdkn2a, Atrx, and Pten to promote glioma formation in vivo [31]. The gene discussed is ATRX; the disease is central nervous system cancer.