In IDH1-mutant astrocytoma cases with available clinical and CNA data (total 161 cases), we found that tumors harboring either CDKN2A deletion, PDGFRA amplification, CDK4 amplification, or MDM2 amplification conferred poor prognosis in these cohorts (Additional file 1: Fig. S5A-B). Here, MDM2 is linked to astrocytoma (excluding glioblastoma).