Peng et al. demonstrated that miR-592 showed a significant down-regulation in glioma cell lines and tissue samples, and further studies revealed that overexpression of miR-592 significantly reduced cell proliferation, migration and invasiveness and arrest of cells in G0 phase and induced G1/migration in vitro by inhibiting IGFBP2 expression [30]. The gene discussed is IGFBP2; the disease is central nervous system cancer.