In LIHC cancer cell Huh7 xenografts, knockdown of METTL3 or treatment with STM2457 resulted in decreased m6A modification and up-regulated expression of DUSP5 and SPRY2, suggesting that METTL3 suppression has a repression effect on the MAPK cascades (Fig. 7A, B) [49–51]. Here, SPRY2 is linked to cancer.