Notably, METTL3 expression exhibited positive associations with macrophage infiltration in UVM, LIHC, and DLBC, while negative correlations were observed in UCEC, SARC, LGG, KRP KIRC, GBM, CESC, and BRCA-LumA (Additional file 2: Figure S2B). The gene discussed is METTL3; the disease is glioblastoma.