IL-4, IL-6 or TNF-α immunoreactive MCs can be detected using IHC in biopsies of patients with allergic asthma, or atopic dermatitis, [40, 41], and IL-13 exposure could change asthma phenotypes [42], confirming IL-4, IL-6, IL-13 and TNF-α could participate in the pathogenesis of allergic diseases. This evidence concerns the gene IL4 and allergic disease.