PIK3CA and neoplasm: Mice injected with HrasG12V, miRp53, and PI3KE545K (Hras/miRp53 + PI3K) (n = 5) showed tumor formation significantly more than mice injected with HrasG12V and miRp53 (Hras/miRp53) (n = 5) (P < 0.05) (Fig. 6D).